Journal: International Journal of Women's Health
Article Title: Prediction of Cervical Cancer Progression Leveraging HPV16 Integration-Related Genes
doi: 10.2147/IJWH.S543345
Figure Lengend Snippet: NRF2 signaling inhibition sensitizes CC cells to cisplatin treatment. ( A ) IC50 values of HeLa, SiHa and C33A cells treated with cisplatin for 48 h. The data are representative of 3 biological replicates. ( B ) IC50 values of HeLa, SiHa and C33A cells treated with cisplatin for 48 h. Cells were pretreated with ML385 (1 µM) for 2 hours prior to cisplatin exposure, with ML385 maintained throughout the entire treatment period. The data are representative of 3 biological replicates. ( C ) RT-qPCR showing the mRNA expression of NQO1 in CC cell lines. Cells were pretreated with ML385 (1 µM) for 2 hours prior to cisplatin exposure. The data are representative of 3 biological replicates. ( D ) Representative histograms and gMFI of DCFH-DA in SiHa and HeLa cells. The data are representative of 3 biological replicates. *p< 0.05, **p< 0.01, ***p< 0.001.
Article Snippet: Human CC cell line HeLa, SiHa and C33A were obtained from the American Type Culture Collection (ATCC).
Techniques: Inhibition, Quantitative RT-PCR, Expressing